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A logical relationship for schizophrenia, bipolar, and major depressive disorder. Part 1: Evidence from chromosome 1 high density association screen
Author(s) -
Zhang Zhihua,
Chen Gang
Publication year - 2020
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.24921
Subject(s) - bipolar disorder , schizophrenia (object oriented programming) , single nucleotide polymorphism , major depressive disorder , psychiatry , genetic association , psychosis , population , genetics , biology , psychology , clinical psychology , medicine , gene , genotype , mood , environmental health
Familial clustering of schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD) was investigated systematically (Aukes et al., Genetics in Medicine, 2012, 14, 338–341) and any two or even three of these disorders could coexist in some families. Furthermore, evidence from symptomatology and psychopharmacology also imply the existence of intrinsic connections between these three major psychiatric disorders. A total of 71,445 SNPs on chromosome 1 were genotyped on 119 SCZ, 253 BPD (type‐I), 177 MDD cases and 1000 controls and further validated in 986 SCZ patients in the population of Shandong province of China. Outstanding psychosis genes are systematically revealed( ATP1A4 , ELTD1 , FAM5C , HHAT , KIF26B , LMX1A , NEGR1 , NFIA , NR5A2 , NTNG1 , PAPPA2 , PDE4B , PEX14 , RYR2 , SYT6 , TGFBR3 , TTLL7 , and USH2A ). Unexpectedly, flanking genes for up to 97.09% of the associated SNPs were also replicated in an enlarged cohort of 986 SCZ patients. F rom the perspective of etiological rather than clinical psychiatry, bipolar, and major depressive disorder could be subtypes of schizophrenia. Meanwhile, the varied clinical feature and prognosis might be the result of interaction of genetics and epigenetics, for example, irreversible or reversible shut down, and over or insufficient expression of certain genes, which may gives other aspects of these severe mental disorders.