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The functional anatomy of cognitive control: A domain‐general brain network for uncertainty processing
Author(s) -
Wu Tingting,
Chen Caiqi,
Spagna Alfredo,
Wu Xia,
Mackie MelissaAnn,
RussellGiller Shira,
Xu Pengfei,
Luo Yuejia,
Liu Xun,
Hof Patrick R.,
Fan Jin
Publication year - 2020
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.24804
Subject(s) - intraparietal sulcus , neuroscience , cognition , working memory , dorsolateral prefrontal cortex , anterior cingulate cortex , functional magnetic resonance imaging , prefrontal cortex , cognitive psychology , ventral striatum , psychology , cingulate cortex , default mode network , biology , striatum , dopamine , central nervous system
Cognitive control is the coordination of mental operations under conditions of uncertainty in accordance with goal‐directed behaviors, and plays a key role in the domains of executive control, working memory, and decision‐making. Although there is emerging evidence of common involvement of the cognitive control network (CCN) of the brain in these domains, this network has mostly been linked to the processing of conflict, which is just one case of an increase in uncertainty. Here, we conducted an activation‐likelihood‐estimation‐based large‐scale meta‐analysis of 289 functional magnetic resonance imaging studies in the three domains to examine the common involvement of the CCN in uncertainty processing by contrasting the high‐uncertainty versus low‐uncertainty conditions. We found a general association between increase in uncertainty and an activation increase in regions of the CCN, including the frontoparietal network (comprising the frontal eye fields, the areas near and along the intraparietal sulcus, and the dorsolateral prefrontal cortex), the cingulo‐opercular network (including the anterior cingulate cortex extending to the supplementary motor area, and the anterior insular cortex), and a subcortical structure (the striatum). These results demonstrate that the CCN is a domain‐general construct underlying uncertainty processing to support goal‐directed behaviors.