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A novel relationship for schizophrenia, bipolar and major depressive disorder Part 3: Evidence from chromosome 3 high density association screen
Author(s) -
Chen Xing,
Long Feng,
Cai Bin,
Chen Xiaohong,
Chen Gang
Publication year - 2018
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.24311
Subject(s) - single nucleotide polymorphism , bipolar disorder , schizophrenia (object oriented programming) , snp , genetics , biology , major depressive disorder , population , genetic association , chromosome , psychiatry , psychology , gene , medicine , neuroscience , genotype , cognition , environmental health
Familial clustering of schizophrenia (SCZ), bipolar disorder (BPD), and major depressive disorder (MDD) was systematically reported (Aukes et al, Genet Med 2012, 14, 338‐341) and convergent evidence from genetics, symptomatology, and psychopharmacology imply that there are intrinsic connections between these three major psychiatric disorders, for example, any two or even three of these disorders could co‐exist in some families. A total of 60, 838 single‐nucleotide polymorphisms (SNPs) on chromosome 3 were genotyped by Affymetrix Genome‐Wide Human SNP array 6.0 on 119 SCZ, 253 BPD (type‐I), 177 MDD patients and 1,000 controls. The population of Shandong province was formed in 14 century and believed that it belongs to homogenous population. Associated SNPs were systematically revealed and outstanding susceptibility genes ( CADPS, GRM7,KALRN, LSAMP, NLGN1, PRICKLE2, ROBO2 ) were identified. Unexpectedly, flanking genes for the associated SNPs distinctive for BPD and/or MDD were replicated in an enlarged cohort of 986 SCZ patients. The evidence from this chromosome 3 analysis supports the notion that both of bipolar and MDD might be subtypes of schizophrenia rather than independent disease entity. Also, a similar finding was detected on chromosome 5, 6, 7, and 8 (Chen et al. Am J Transl Res 2017;9 (5):2473–2491; Curr Mol Med 2016;16(9):840–854; Behav Brain Res 2015;293:241–251; Mol Neurobiol 2016. doi: 10.1007/s12035‐016‐0102‐1). Furthermore, PRICKLE2 play an important role in the pathogenesis of three major psychoses in this population.