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Myelin and oligodendrocyte development in the canine spinal cord
Author(s) -
Mayer Joshua A.,
Figari Carlos,
Radcliff Abigail B.,
Mckee Camille,
Duncan Ian D.
Publication year - 2015
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.23882
Subject(s) - spinal cord , oligodendrocyte , biology , myelin , neuroscience , anatomy , central nervous system , white matter , cord , magnetic resonance imaging , medicine , radiology , geometry , mathematics
We studied the developmental pattern of oligodendrocyte differentiation and myelin formation in the fetal canine spinal cord from E40 to P0. The pattern of development matches what has been described in the spinal cord of humans, rodents, and many other species. Oligodendrocytes were first found at E40, close to the central canal, with their spread in a tangential manner to the ventral and then lateral columns. Myelin development followed the same pattern but was not seen until E46. A clear subpial zone lacking glial cells and myelin was seen in the lateral column in early development, suggesting that there may also be a radial component of migration of oligodendrocyte progenitor cells (OPCs) from a ventral site. This spatial–temporal developmental pattern seen in wild type matches a delay in myelination of the superficial tracts of the spinal cord seen in a canine myelin mutant, suggesting that the mutation prevents the distribution and differentiation of OPCs at an early, but narrow, window of time during fetal development. J. Comp. Neurol. 524:930–939, 2016. © 2015 Wiley Periodicals, Inc.