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Organization of TNIK in dendritic spines
Author(s) -
Burette Alain C.,
Phend Kristen D.,
Burette Susan,
Lin Qingcong,
Liang Musen,
Foltz Gretchen,
Taylor Noël,
Wang Qi,
Brandon Nicholas J.,
Bates Brian,
Ehlers Michael D.,
Weinberg Richard J.
Publication year - 2015
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.23770
Subject(s) - dendritic spine , neuroscience , glutamatergic , microbiology and biotechnology , biology , traf2 , interactor , tumor necrosis factor alpha , receptor , glutamate receptor , immunology , hippocampal formation , biochemistry , tumor necrosis factor receptor
Tumor necrosis factor receptor‐associated factor 2 (TRAF2)‐ and noncatalytic region of tyrosine kinase (NCK)‐interacting kinase (TNIK) has been identified as an interactor in the psychiatric risk factor, Disrupted in Schizophrenia 1 (DISC1). As a step toward deciphering its function in the brain, we performed high‐resolution light and electron microscopic immunocytochemistry. We demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain. In striatum and cerebral cortex, TNIK concentrates in dendritic spines, especially in the vicinity of the lateral edge of the synapse. Thus, TNIK is highly enriched at a microdomain critical for glutamatergic signaling. J. Comp. Neurol. 523:1913–1924, 2015 © 2015 Wiley Periodicals, Inc.