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Collateral branching of long‐distance cortical projections in monkey
Author(s) -
Rockland Kathleen S.
Publication year - 2013
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.23414
Subject(s) - biology , neuroscience , axon , branching (polymer chemistry) , projection (relational algebra) , anatomy , computer science , materials science , algorithm , composite material
ABSTRACT Collateralization of individual cortical axons is well documented for rodents but less so for monkeys, where double retrograde tracer experiments have tended to find only small numbers of neurons projecting to two different injection sites. Evidence from both double label and single axon studies, however, suggests that in specific projection systems the number of neurons with collateralized axons can be 10% or greater. These include feedback projections from temporal areas (but less so those from V4 and MT/V5). Single‐axon analyses show that many parietal neurons branch to multiple targets. Except for giant Meynert cells in area V1, feedforward projections from early visual areas have only a small number of neurons with branching axons. Why only some neurons collateralize, what determines branch points and projection foci, and how this impacts network organization are largely unknown. Deciphering the branching code might offer new perspectives on space‐time organization at the network level. J. Comp. Neurol. 521:4112–4123, 2013. © 2013 Wiley Periodicals, Inc.