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Postnatal expression of TrkB receptor in rat vestibular nuclear neurons responsive to horizontal and vertical linear accelerations
Author(s) -
Ma ChunWai,
Zhang FuXing,
Lai ChunHong,
Lai SukKing,
Yung Ken KinLam,
Shum Daisy KwokYan,
Chan YingShing
Publication year - 2012
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.23193
Subject(s) - tropomyosin receptor kinase b , vestibular nuclei , vestibular system , biology , neuroscience , neurotrophin , medial vestibular nucleus , nucleus , anatomy , neurotrophic factors , receptor , biochemistry
We examined the maturation expression profile of tyrosine kinase B (TrkB) receptor in rat vestibular nuclear neurons that were activated by sinusoidal linear acceleration along the horizontal or vertical axis. The otolithic origin of Fos expression in these neurons was confirmed with labyrinthectomized controls and normal controls, which showed only sporadically scattered Fos‐labeled neurons in the vestibular nucleus. In P4–6 test rats, no Fos‐labeled neurons were found in the vestibular nucleus, but the medial and spinal vestibular neurons showed weak immunoreactivity for TrkB. The intensity of TrkB immunoreactivity in vestibular nuclear neurons progressively increased in the second postnatal week but remained low in adults. From P7 onward, TrkB‐expressing neurons responded to horizontal or vertical otolithic stimulation with Fos expression. The number of Fos‐labeled vestibular nuclear neurons expressing TrkB increased with age, from 13–43% in P7 rats to 85–90% in adult rats. Our results therefore suggest that TrkB/neurotrophin signaling plays a dominant role in modulating vestibular nuclear neurons for the coding of gravity‐related horizontal head movements and for the regulation of vestibular‐related behavior during postnatal development. J. Comp. Neurol. 521:612–625, 2013. © 2012 Wiley Periodicals, Inc.