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Phox2b expression in the taste centers of fish
Author(s) -
Coppola Eva,
D'autréaux Fabien,
Nomaksteinsky Marc,
Brunet JeanFrançois
Publication year - 2012
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.23117
Subject(s) - biology , danio , zebrafish , sensory system , taste , solitary tract , carassius auratus , nucleus , anatomy , vertebrate , homeobox , neuroscience , gene , transcription factor , genetics , fish <actinopterygii> , fishery
The homeodomain transcription factor Phox2b controls the formation of the sensory‐motor reflex circuits of the viscera in vertebrates. Among Phox2b ‐dependent structures characterized in rodents is the nucleus of the solitary tract, the first relay for visceral sensory input, including taste. Here we show that Phox2b is expressed throughout the primary taste centers of two cyprinid fish, Danio rerio and Carassius auratus , i.e., in their vagal, glossopharyngeal, and facial lobes, providing the first molecular evidence for their homology with the nucleus of the solitary tract of mammals and suggesting that a single ancestral Phox2b‐positive neuronal type evolved to give rise to both fish and mammalian structures. In zebrafish larvae, the distribution of Phox2b + neurons, combined with the expression pattern of Olig4 (a homologue of Olig3 , determinant of the nucleus of the solitary tract in mice), reveals that the superficial position and sheet‐like architecture of the viscerosensory column in cyprinid fish, ideally suited for the somatotopic representation of oropharyngeal and bodily surfaces, arise by radial migration from a dorsal progenitor domain, in contrast to the tangential migration observed in amniotes. J. Comp. Neurol. 520:3633–3649, 2012. © 2012 Wiley Periodicals, Inc.