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Regional and subcellular distribution of the receptor‐targeting protein PIST in the rat central nervous system
Author(s) -
Chen Annie,
Göβling Enno K.,
Witkowski Leora,
Bhindi Amar,
Bauch Carola,
Roussy Geneviève,
Sarret Philippe,
Kreienkamp HansJürgen,
Stroh Thomas
Publication year - 2012
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.23036
Subject(s) - biology , postsynaptic potential , inhibitory postsynaptic potential , neuroligin , neuroscience , central nervous system , excitatory postsynaptic potential , microbiology and biotechnology , receptor , biochemistry
A hippocampal neuron in primary culture stained with anti‐PIST (red) and anti‐neuroligin‐2 (green), a postsynaptic cell adhesion protein which is exclusively located at inhibitory synapses. The nucleus was stained with DAPI (blue). Note the typical distribution of neuroligin‐2 immunoreactivity reminiscent of inhibitory synapses at proximal dendrites and cell body, which is not matched by the PIST immunofluorescence signal. The latter is concentrated in the perikaryon in a juxtanuclear position and appears to be absent from postsynaptic sites. The Journal of Comparative Neurology, Volume 520, Number 5, pages 889–913.