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Kv7.5 is the primary Kv7 subunit expressed in C‐fibers
Author(s) -
King Chih H.,
Scherer Steven S.
Publication year - 2012
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.23019
Subject(s) - neuroscience , protein subunit , sensory system , dorsal root ganglion , tropomyosin receptor kinase a , potassium channel , nociception , chemistry , enhancer , dorsum , microbiology and biotechnology , biology , biophysics , nerve growth factor , anatomy , receptor , biochemistry , gene , gene expression
Kv7 (KCNQ) potassium channel openers (enhancers) decrease neuropathic pain in experimental models. Here we show that C‐fibers, and their associated small‐diameter neurons in the dorsal root ganglia (both IB4‐ and TrkA‐positive), expressed Kv7.5. In contrast, C‐fibers did not express detectable levels of Kv7.2 or Kv7.3, which are instead localized to nodes of Ranvier and the cell bodies of large sensory neurons. These data suggest that Kv7.5 provides the primary M current in nociceptive neurons. J. Comp. Neurol. 520:1940–1950, 2012. © 2011 Wiley Periodicals, Inc.