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Cytoarchitecture of the lateral ganglionic eminence and rostral extension of the lateral ventricle in the human fetal brain
Author(s) -
GuerreroCázares Hugo,
GonzalezPerez Oscar,
SorianoNavarro Mario,
ZamoraBerridi Grettel,
GarcíaVerdugo José Manuel,
QuinoñesHinojosa Alfredo
Publication year - 2011
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.22566
Subject(s) - neuroblast , olfactory bulb , subventricular zone , rostral migratory stream , cytoarchitecture , biology , neuroscience , anatomy , lateral ventricles , neurogenesis , ganglionic eminence , neural stem cell , central nervous system , microbiology and biotechnology , stem cell , cerebrum
The fetal development of the anterior subventricular zone (SVZ) involves the transformation of radial glia into neural stem cells, in addition to the migration of neuroblasts from the SVZ towards different regions in the brain. In adult rodents this migration from the anterior SVZ is restricted to the olfactory bulb following a rostral migratory stream (RMS) formed by chains of migratory neuroblasts. Similar to rodents, an RMS has been suggested in the adult human brain, where the SVZ remains as an active proliferative region. Nevertheless, a human fetal RMS has not been described and the presence of migratory neuroblasts in the adult remains controversial. Here we describe the cytoarchitecture of the human SVZ at the lateral ganglionic eminence late in the second trimester of development (23–24 weeks postconception). Cell organization in this region is heterogeneous along the ventricular wall, with GFAP‐positive cells aligned to the ventricle. These cells coexpress markers for radial glia like GFAPδ, nestin, and vimentin. We also show the presence of abundant migratory neuroblasts in the anterior horn SVZ forming structures here denominated cell throngs. Interestingly, a ventral extension of the lateral ventricle suggests the presence of a putative RMS. Nevertheless, in the olfactory bulb neuroblast throngs or chain‐like structures were not observed. The lack of these structures closer to the olfactory bulb could indicate a destination for the migratory neuroblasts outside the olfactory bulb in the human brain. J. Comp. Neurol. 519:1165–1180, 2011. © 2010 Wiley‐Liss, Inc.