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Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines
Author(s) -
Christie LoriAnn,
Saunders Richard C.,
Kowalska Danuta M.,
MacKay William A.,
Head Elizabeth,
Cotman Carl W.
Publication year - 2008
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.21821
Subject(s) - neuroscience , prefrontal cortex , dorsolateral prefrontal cortex , psychology , working memory , recognition memory , temporal lobe , spatial memory , short term memory , frontal lobe , cognitive neuroscience of visual object recognition , stimulus (psychology) , cognitive psychology , cognition , object (grammar) , artificial intelligence , computer science , epilepsy
To examine the effects of rhinal and dorsolateral prefrontal cortex lesions on object and spatial recognition memory in canines, we used a protocol in which both an object (delayed nonmatching to sample, or DNMS) and a spatial (delayed nonmatching to position or DNMP) recognition task were administered daily. The tasks used similar procedures such that only the type of stimulus information to be remembered differed. Rhinal cortex (RC) lesions produced a selective deficit on the DNMS task, both in retention of the task rules at short delays and in object recognition memory. By contrast, performance on the DNMP task remained intact at both short and long delay intervals in RC animals. Subjects who received dorsolateral prefrontal cortex (dlPFC) lesions were impaired on a spatial task at a short, 5‐second delay, suggesting disrupted retention of the general task rules; however, this impairment was transient, and long‐term spatial memory performance was unaffected in dlPFC subjects. The present results provide support for the involvement of the RC in object, but not visuospatial, processing and recognition memory, whereas the dlPFC appears to mediate retention of a nonmatching rule. These findings support theories of functional specialization within the medial temporal lobe and frontal cortex and suggest that rhinal and dorsolateral prefrontal cortices in canines are functionally similar to analogous regions in other mammals. J. Comp. Neurol. 511:257–270, 2008. © 2008 Wiley‐Liss, Inc.