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Calcitonin receptor‐like receptor (CLR), receptor activity‐modifying protein 1 (RAMP1), and calcitonin gene‐related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution
Author(s) -
Lennerz Jochen K.,
Rühle Victor,
Ceppa Eugene P.,
Neuhuber Winfried L.,
Bunnett Nigel W.,
Grady Eileen F.,
Messlinger Karl
Publication year - 2008
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.21654
Subject(s) - calcitonin gene related peptide , calcitonin receptor , receptor , biology , medicine , calcitonin , endocrinology , anatomy , neuropeptide
CGRP meets its receptor in the rat dura mater. The CGRP receptor protein CLR (green) is expressed in smooth muscle cells (blue, SMA) in the media of meningeal arteries (left) but not in veins (right upper half). CLR is also found in trigeminal nerve bundles and mononuclear cells adjacent to the arteries. CGRP‐receptor components are however not co‐localized with axonal CGRP (red) in the dura, but expressed in Schwann cells (not visible at this magnification). J. Comp. Neurol. 507:1279–1301, 2008. © 2008 Wiley‐Liss, Inc.