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Local Self‐Assembly Mechanisms Underlie the Differential Transformation of the Proximal and Distal Cut Axonal Ends Into Functional and Aberrant Growth Cones
Author(s) -
Erez Hadas,
Spira Micha
Publication year - 2007
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.21632
Subject(s) - growth cone , biology , axotomy , neurite , anatomy , neuroscience , axon , axoplasmic transport , central nervous system , biochemistry , in vitro
Following axotomy both the proximal and distal cut axonal ends transform into growth cones. Whereas the growth cone formed by the tip of the proximal segment branch to form neurites (left hand side), the structure formed by the distal cut end fails to grow. In redmicrotubules, blue ‐ vesicles, and green ‐ actin. J. Comp. Neurol. 507:1019–1030, 2007. © 2007 Wiley‐Liss, Inc.