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Early afferent signaling in the outer plexiform layer regulates development of horizontal cell morphology
Author(s) -
Raven Mary E.,
Orton Noelle C.,
Nassar Hadi,
Williams Gary A.,
Stell William K.,
Jacobs Gerald H.,
BechHansen N. Torben,
Reese Benjamin E.
Publication year - 2007
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.21609
Subject(s) - outer plexiform layer , ribbon synapse , inner plexiform layer , biology , retina , microbiology and biotechnology , outer nuclear layer , anatomy , neuroscience , biophysics , synaptic vesicle , biochemistry , vesicle , membrane
The pedicles of cone photoreceptors, labeled with an antibody to mouse cone arrestin (blue), stratify in the outer plexiform layer, where they form synapses with the dendrites of horizontal and bipolar cells. Those synaptic sites are evidenced by the co‐localization of the synaptic ribbon protein, piccolo (red), with the cone arrestin labeling. The remaining red profiles in the outer plexiform layer indicate the sites of the rod spherules. An antibody to cytochrome oxidase (green) labels the mitochondrion‐rich inner segments of all photoreceptors and yields punctate peri‐nuclear labeling within the outer nuclear layer. Many of these features of the outer retina are altered in the Cacna1f‐mutant retina, expressing a defective calcium channel subunit that prevents normal neurotransmission in the outer plexiform layer. J. Comp. Neurol. 506:745–758, 2007. © 2007 Wiley‐Liss, Inc.