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Forebrain substrates of reward and motivation
Author(s) -
Wise Roy A.
Publication year - 2005
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.20689
Subject(s) - medial forebrain bundle , reward system , dopamine , neuroscience , forebrain , arousal , psychology , brain stimulation reward , addiction , stimulation , basal forebrain , motor system , central nervous system , striatum , nucleus accumbens
Electrical stimulation of the medial forebrain bundle can reward arbitrary acts or motivate biologically primitive, species‐typical behaviors like feeding or copulation. The subsystems involved in these behaviors are only partially characterized, but they appear to transsynaptically activate the mesocorticolimbic dopamine system. Basal function of the dopamine system is essential for arousal and motor function; phasic activation of this system is rewarding and can potentiate the effectiveness of reward‐predictors that guide learned behaviors. This system is phasically activated by most drugs of abuse and such activation contributes to the habit‐forming actions of these drugs. J. Comp. Neurol. 493:115–121, 2005. Published 2005 Wiley‐Liss, Inc.