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Ltrk is differentially expressed in developing and adult neurons of the Lymnaea central nervous system
Author(s) -
Bulloch Andrew G.M.,
Diep Chi Q.,
Logan Cairine C.,
Bulloch Estrella S.,
Robbins Stephen M.,
Hislop Jonathan,
Sossin Wayne S.
Publication year - 2005
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.20575
Subject(s) - biology , lymnaea , in situ hybridization , neuroscience , central nervous system , vertebrate , trk receptor , nervous system , axon , juvenile , spinal cord , lymnaea stagnalis , receptor , messenger rna , neurotrophin , genetics , ecology , snail , gene
The Trk receptor family plays diverse roles in both development and plasticity of the vertebrate nervous system. Ltrk is a related receptor that is expressed in the CNS of the mollusk Lymnaea , although little is known of its cellular distribution. This study provides three independent lines of evidence (based on RT‐PCR, in situ hybridization, and immunohistochemistry) that Ltrk is universally expressed by neurons and dorsal body cells of both the juvenile and the adult Lymnaea CNS. The highest level of expression by neuronal somata occurs in the late juvenile stage, whereas axon collaterals express high levels throughout the animal's life span. Our data support multifunctional roles for Ltrk that parallel those of its mammalian counterparts. J. Comp. Neurol. 487:240–254, 2005. © 2005 Wiley‐Liss, Inc.