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Neuronal and astrocyte expression of nicotinic receptor subunit β4 in the adult mouse brain
Author(s) -
Gahring Lorise C.,
Persiyanov Karina,
Rogers Scott W.
Publication year - 2003
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.10942
Subject(s) - biology , neuroscience , interpeduncular nucleus , piriform cortex , olfactory bulb , hippocampal formation , nicotinic acetylcholine receptor , olfactory tubercle , sensory system , nicotinic agonist , hippocampus , receptor , central nervous system , midbrain , biochemistry
Neuronal nicotinic acetylcholine receptor (nAChR) expression and function are customized in different brain regions through assembling receptors from closely related but genetically distinct subunits. Immunohistochemical analysis of one of these subunits, nAChRβ4, in the mouse brain suggests an extensive and potentially diverse role for this subunit in both excitatory and inhibitory neurotransmission. Prominent immunostaining included: 1) the medial habenula, efferents composing the fasciculus retroflexus, and the interpeduncular nucleus; 2) nuclei and ascending tracts of the auditory system inclusive of the medial geniculate; 3) the sensory cortex barrel field and cell bodies of the ventral thalamic nucleus; 4) olfactory‐associated structures and the piriform cortex; and 5) sensory and motor trigeminal nuclei. In the hippocampus, nAChRβ4 staining was limited to dendrites and soma of a subset of glutamic acid dehydrogenase‐positive neurons. In C57BL/6 mice, but to a lesser extent in C3H/J, CBA/J, or CF1 mice, a subpopulation of astrocytes in the hippocampal CA1 region prominently expressed nAChRβ4 (and nAChRα4). Collectively, these results suggest that the unique functional and pharmacological properties exerted by nAChRβ4 on nAChR function could modify and specialize the development of strain‐specific sensory and hippocampal‐related characteristics of nicotine sensitivity including the development of tolerance. J. Comp. Neurol. 468:322–333, 2004. © 2003 Wiley‐Liss, Inc.