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Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain
Author(s) -
Pieribone Vincent A.,
Porton Barbara,
Rendon Beatrice,
Feng Jian,
Greengard Paul,
Kao HungTeh
Publication year - 2002
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/cne.10417
Subject(s) - synapsin , synapsin i , olfactory bulb , biology , dentate gyrus , neuroscience , neurogenesis , hippocampal formation , neurotransmitter , synaptic vesicle , central nervous system , microbiology and biotechnology , vesicle , biochemistry , membrane
We have examined the distribution of synapsin III in the adult mouse brain. Expression of synapsin III was observed in puncta throughout the brain, but demonstrated greater regional variation than that of synapsins I or II. This punctate staining is typical for synaptic vesicle proteins located at nerve terminals. These findings are also consistent with the well‐established role for synapsins in regulating neurotransmitter release. However, unexpectedly, synapsin III was also highly expressed in the cell body and processes of immature neurons in neurogenic regions of the adult brain, such as the hippocampal dentate gyrus, rostral migratory stream, and olfactory bulb. Many synapsin III‐positive neurons also reacted with an antibody directed toward polysialylated‐neuronal cell adhesion molecule, a marker of immature, migrating neurons. These results suggest that synapsin III may also play a role in adult neurogenesis. J. Comp. Neurol. 454:105–114, 2002. © 2002 Wiley‐Liss, Inc.