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Application of the Milan System for Reporting Pediatric Salivary Gland Cytopathology: Analysis of histologic follow‐up, risk of malignancy, and diagnostic accuracy
Author(s) -
Wang Huiying,
Weiss Vivian Lee,
Borinstein Scott C.,
Ely Kim,
Johnson Joyce,
Coogan Alice,
Belcher Ryan,
Mannion Kyle,
Virgin Frank,
Liang Jiancong
Publication year - 2021
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.29
H-Index - 57
eISSN - 1934-6638
pISSN - 1934-662X
DOI - 10.1002/cncy.22415
Subject(s) - cytopathology , medicine , atypia , malignancy , salivary gland , fine needle aspiration , pathology , population , radiology , cytology , biopsy , environmental health
Background The diagnosis and management of salivary gland tumors in pediatric patients can be challenging. The utility of fine‐needle aspiration (FNA) cytopathology and the performance of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) in this age group have not been systematically assessed. The paucity of data has contributed to the controversial role of FNA cytopathology in the presurgical management of these patients. Methods The authors retrospectively analyzed 104 pediatric salivary gland FNAs (2000‐2020). A correlation with the available histopathologic follow‐up (n = 54) was performed. The distribution percentages, the risk of neoplasm (RON), and the risk of malignancy (ROM) were assessed for each category of the MSRSGC. Results The overall sensitivity, specificity, negative predictive value, and positive predictive value of pediatric salivary gland FNAs were 80%, 97%, and 92%, respectively. The RON values for the nondiagnostic, nonneoplastic, atypia of undetermined significance, benign neoplasm, salivary gland neoplasm of uncertain malignant potential, suspicious for malignancy, and malignant categories were 60%, 11%, 100%, 100%, 100%, 100%, and 100%, respectively, whereas the ROM values were 0%, 11%, 100%, 6%, 67%, 100%, and 100%, respectively. The percentage of nonneoplastic FNAs was greater in comparison with the adult population (52% vs 8%). All neoplasms in patients aged 0 to 10 years were malignant, whereas benign neoplasms occurred only in patients aged ≥11 years; this supported an inverse correlation between age and malignancy rate in salivary gland neoplasms. Conclusions FNA cytopathology demonstrates excellent diagnostic performance in differentiating malignant and benign pediatric salivary gland lesions. The MSRSGC is a valuable tool for standardization of the reporting and preoperative risk stratification of these lesions.