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Racial differences in HPV type 16 prevalence in women with ASCUS of the uterine cervix
Author(s) -
Risley Carolann,
Clarke Megan A.,
Geisinger Kim R.,
Stewart Mary W.,
Zhang Lei,
Hoover Kim W.,
Hiser Laree M.,
Owens Kenyata,
DeMarco Maria,
Schiffman Mark,
Wentzensen Nicolas
Publication year - 2020
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.29
H-Index - 57
eISSN - 1934-6638
pISSN - 1934-662X
DOI - 10.1002/cncy.22267
Subject(s) - ascus (bryozoa) , medicine , squamous intraepithelial lesion , colposcopy , gynecology , odds ratio , obstetrics , population , cytology , papanicolaou stain , cervical cancer , cervix , cervical intraepithelial neoplasia , cancer , pathology , biology , botany , ascospore , spore , environmental health
Background Understanding racial influences on human papillomavirus (HPV) distribution in women with atypical squamous cells of undetermined significance (ASCUS) cytology via partial genotyping in a statewide population can inform HPV‐based prevention efforts. Methods Women aged 21 to 65 years with any cytology result and partial HPV genotyping for ASCUS triage between January 1, 2014, and December 31, 2017, were included. All women attended a Mississippi State Department of Health clinic. Age, race, cytopathologic, and HPV data were extracted from the electronic health record and analyzed. Cytologic specimens were processed with ThinPrep and HPV testing with the Cobas 4800 assay. HPV genotypes were evaluated in hierarchical categories. Chi‐square tests and multinomial logistic regression models evaluated associations between race and type prevalence. Results There were 43,106 women who underwent cervical cancer screening with cytology and ASCUS triage. Of these, 34,363 (80.2%) had normal cytology, 4672 (10.9%) had ASCUS, 2683 (6.3%) had a low‐grade squamous intraepithelial lesion, and 633 (1.5%) had a high‐grade squamous intraepithelial lesion. Blacks represented 69.3% of the sample and had a higher proportion of HPV‐positive ASCUS (6.5%) in comparison with whites (5.6%). Blacks had significantly decreased odds of HPV‐16 (odds ratio [OR], 0.66; 95% confidence interval [CI], 0.6‐0.9; P = .002) and significantly increased odds for 12 other types (OR, 1.37; 95% CI, 1.2‐1.5; P < .0001) in comparison with whites. Conclusions In a diverse population, significant differences in HPV genotypes are shown by race. Importantly, blacks with ASCUS are less likely to be positive for HPV‐16 in comparison with whites. Ongoing work is evaluating the individual genotype prevalence and genotype‐specific risk of precancer by race.