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Prevalence of HPV‐16/18 genotypes and immediate histopathologic correlation results in a Chinese population with negative cytology and positive high‐risk HPV testing
Author(s) -
Tao Xiang,
Zhang Huina,
Li Juan,
Zhang Hao,
Xiao Jianan,
Zhang Lihong,
Zhou Xianrong,
Sui Long,
Wang Li,
Zhao Chengquan
Publication year - 2019
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.29
H-Index - 57
eISSN - 1934-6638
pISSN - 1934-662X
DOI - 10.1002/cncy.22180
Subject(s) - medicine , cytology , papanicolaou stain , cervical intraepithelial neoplasia , cervical cancer , gynecology , squamous intraepithelial lesion , population , malignancy , human papillomavirus , ascus (bryozoa) , cancer , gastroenterology , pathology , botany , ascospore , environmental health , spore , biology
Background The objective of this study was to examine the prevalence of human papillomavirus 16/18 (HPV‐16/18) genotypes and immediate histopathologic correlations in a Chinese population with negative cytology and positive high‐risk human papillomavirus (hrHPV) testing. Methods Patients who had documented negative cytology with immediate follow‐up (within the 6 months after negative for intraepithelial lesion or malignancy Papanicolaou [Pap] testing), including a histopathologic examination and/or hrHPV testing, between 2011 and 2018 were included, and the data were analyzed. Results Among 1,424,182 Pap tests, 1,333,453 (93.6%) were interpreted as negative cytology. Although conventional Pap smears had the highest reporting rate, cervical intraepithelial neoplasia 2 and higher (CIN‐2+) lesions were detected significantly more with liquid‐based cytology preparations (2.1%) than the conventional method (1.4%; P < .01). The overall hrHPV‐positive rate was 14.9% (25,507 of 171,273) in the women with negative cytology. Among the 18,423 cytology‐negative, HPV‐positive cases tested with the Cobas assay, the overall HPV‐16/18 prevalence was 24.7%, with 17.9% being HPV‐16–positive, 6.2% being HPV‐18–positive, and 0.6% being positive for both HPV‐16 and HPV‐18. The immediate histopathologic examination was documented for 21,796 women with cotesting results, including 8915 HPV‐positive cases and 12,881 HPV‐negative cases. CIN‐2+ lesions were diagnosed in 15.2% of the HPV‐16–positive cases; this rate was significantly higher than the rates seen in the HPV‐18–positive cases (4.8%) and the cases positive for 1 of the other 12 types of HPV (3.0%). Conclusions This is by far the largest routine clinical practice report of HPV‐16/18 genotyping and histopathologic examination in negative‐cytology women and the first report of such an investigation in the Chinese population. This study indicates enhanced risk stratification with HPV‐16/18 genotype testing in HPV‐positive, cytology‐negative women in the Chinese population.