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Immunohistochemical validation studies in effusion cytology: A cautionary tale
Author(s) -
Pillappa Raghavendra,
Kraft Adele O.
Publication year - 2019
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.29
H-Index - 57
eISSN - 1934-6638
pISSN - 1934-662X
DOI - 10.1002/cncy.22149
Subject(s) - medicine , immunohistochemistry , effusion , cytology , pathology , surgery
Besides the established uses in tumor diagnosis and characterization, immunohistochemical assays of effusion fluids are being increasingly used as substrates for prognostic and predictive markers. This commentary highlights validation issues encountered in daily practice that may have an impact on assay interpretation.