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Core‐needle biopsy of breast cancer is associated with a higher rate of distant metastases 5 to 15 years after diagnosis than FNA biopsy
Author(s) -
Sennerstam Roland B.,
Franzén Bo S. H.,
Wiksell Hans O. T.,
Auer Gert U.
Publication year - 2017
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.29
H-Index - 57
eISSN - 1934-6638
pISSN - 1934-662X
DOI - 10.1002/cncy.21909
Subject(s) - medicine , biopsy , breast cancer , fine needle aspiration , mammography , metastasis , cancer , distant metastasis , radiology
BACKGROUND The literature offers discordant results regarding whether diagnostic biopsy is associated with the dissemination of cancer cells, resulting in local and/or distant metastasis. The long‐term outcomes of patients with breast cancer were compared between those who were diagnosed using either fine‐needle aspiration biopsy (FNAB) or core‐needle biopsy (CNB) during 2 decades: the 1970s and 1990s. METHODS In the 1970s, the only diagnostic needle biopsy method used for breast cancer in Sweden was FNAB. CNB was introduced 1989 and became established in Stockholm Gotland County in the early 1990s. The authors compared the clinical outcomes of patients diagnosed using FNAB from 1971 to 1976 (n = 354) versus those of patients diagnosed using CNB from 1991 to 1995 (n = 1729). Adjusting for differences in various treatment modalities, mammography screening, tumor size, DNA ploidy, and patient age between the 2 decades, 2 strictly matched samples representing FNAB (n = 181) and CNB (n = 203) were selected for a 15‐year follow‐up study. RESULTS In a comparison of the rates of distant metastasis in the strictly matched patient groups from the FNAB and CNB cohorts, significantly higher rates of late‐appearing (5‐15 years after diagnosis) distant metastasis were observed among the patients who were diagnosed on CNB compared with those who were diagnosed on FNAB. No significant difference in local metastasis was observed between the 2 groups. CONCLUSIONS At 5 to 15 years after diagnosis of the primary tumor, CNB‐diagnosed patients had significantly higher rates of distant metastases than FNAB‐diagnosed patients. Cancer Cytopathol 2017;125:748‐56 . © 2017 American Cancer Society .