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Hürthle cells in fine‐needle aspirates of the thyroid: A review of their diagnostic criteria and significance
Author(s) -
Auger Ma
Publication year - 2014
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.29
H-Index - 57
eISSN - 1934-6638
pISSN - 1934-662X
DOI - 10.1002/cncy.21391
Subject(s) - medicine , malignancy , atypia , clinical significance , pathology , thyroid cancer , thyroid , cancer , radiology
Although the cytological assessment of Hürthle cell lesions is challenging, the literature offers good, albeit imperfect, guidance to aid in the crucial distinction between nonneoplastic and neoplastic lesions. The significance of a cytologic diagnosis of follicular neoplasm, Hürthle cell type, lies in the rate of malignancy on follow‐up surgical excision, ranging in the literature from 10% to 45%. A cytodiagnosis of atypia of undetermined significance ( AUS), Hürthle cell type, appears to be associated with a lower risk of malignancy on follow‐up than other subtypes of AUS; however, this area warrants further investigation. Cancer (Cancer Cytopathol) 2014;122:241–249 . © 2014 American Cancer Society .