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Fine‐needle aspiration characteristics of hibernoma
Author(s) -
Lemos Maria M.,
Kindblom LarsGunnar,
MeisKindblom Jeanne M.,
Remotti Fabrizio,
Ryd Walter,
Gunterberg Björn,
Willén Helena
Publication year - 2001
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.9030
Subject(s) - medicine , liposarcoma , fine needle aspiration , confusion , lipoma , lipomatosis , differential diagnosis , pathology , cytology , radiology , fine needle aspiration cytology , biopsy , sarcoma , psychology , psychoanalysis
BACKGROUND Hibernoma is a rare, benign lipomatous tumor with features of brown fat. The preoperative diagnosis of hibernoma is difficult at times because its clinical, radiographic, and fine‐needle aspiration (FNA) characteristics overlap with those of liposarcoma. METHODS The preoperative FNA findings of eight surgically excised hibernomas from seven patients (three men and four women, ages 24–60 years) were reviewed. The cytologic features were compared with the histologic features of the corresponding surgical specimens as well as lipomatous tumors and other lesions that may cause confusion in the differential diagnosis. RESULTS The FNA cytologic features of the hibernomas were found to correspond well with their histologic appearance. The FNA findings included small, round, brown fat‐like cells with uniform, small cytoplasmic vacuoles and regular, small, round nuclei; delicate branching capillaries; and variable numbers of mature fat cells. CONCLUSIONS The FNA cytologic features of hibernoma are characteristic and useful in the preoperative investigation of lipomatous tumors, particularly with regard to excluding a diagnosis of liposarcoma. Cancer (Cancer Cytopathol) 2001;93:206–210. © 2001 American Cancer Society.