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Top advances of the year: Pediatric oncology
Author(s) -
Pappo Alberto S.,
Karol Seth E.,
Bertrand Kelsey C.
Publication year - 2022
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.34425
Subject(s) - medicine , medulloblastoma , pediatric oncology , childhood cancer , neuroblastoma , pediatric cancer , cancer , oncology , intensive care medicine , cancer research , biology , genetics , cell culture
Accelerated discovery and collaborative research continue to highlight the remarkable progress that has been made in the diagnosis and treatment of pediatric cancers. This manuscript highlights important discoveries on how precision oncology is being incorporated into the diagnosis and treatment of childhood cancer at the national level to identify promising new therapies using a tumor‐agnostic approach. In addition, we have highlighted three articles that incorporate genomics and cell‐free DNA to better classify, monitor and incorporate risk‐based therapies for children with medulloblastoma. Finally, we highlighted the important role of monclonal antiobody therapy in the treatment of recurrent B‐cell leukemia and newly diagnosed high‐risk neuroblastoma.