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Negative affect and stress‐related brain metabolism in patients with metastatic breast cancer
Author(s) -
Reis Joaquim C.,
Travado Luzia,
Antoni Michael H.,
Oliveira Francisco P. M.,
Almeida Silvia D.,
Almeida Pedro,
Heller Aaron S.,
Sousa Berta,
Costa Durval C.
Publication year - 2020
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.32902
Subject(s) - ventromedial prefrontal cortex , medicine , insula , prefrontal cortex , breast cancer , stressor , thalamus , standardized uptake value , metastatic breast cancer , cancer , positron emission tomography , oncology , neuroscience , psychology , nuclear medicine , radiology , psychiatry , cognition
Background Cancer and its treatment represent major stressors requiring that patients make multiple adaptations. Despite evidence that poor adaptation to stressors is associated with more distress and negative affect (NA), neuroimmune dysregulation and poorer health outcomes, current understanding is very limited of how NA covaries with central nervous system changes to account for these associations. Methods NA was correlated with brain metabolic activity using 18 F‐fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F‐FDG PET/CT) in several regions of interest in 61 women with metastatic breast cancer. Patients underwent 18 F‐FDG PET/CT and completed an assessment of NA using the Brief Symptom Inventory. Results Regression analyses revealed that NA was significantly negatively correlated with the standardized uptake value ratio of the insula, thalamus, hypothalamus, ventromedial prefrontal cortex, and lateral prefrontal cortex. Voxel‐wise correlation analyses within these 5 regions of interest demonstrated high left‐right symmetry and the highest NA correlations with the anterior insula, thalamus (medial and ventral portion), lateral prefrontal cortex (right Brodmann area 9 [BA9], left BA45, and right and left BA10 and BA8), and ventromedial prefrontal cortex (bilateral BA11). Conclusions The regions of interest most strongly negatively associated with NA represent key areas for successful adaptation to stressors and may be particularly relevant in patients with metastatic breast cancer who are dealing with multiple challenges of cancer and its treatment.