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Impact of prebiopsy magnetic resonance imaging on biopsy and radical prostatectomy grade concordance
Author(s) -
Shoag Jonathan E.,
Cai Peter Y.,
Gross Michael D.,
Gaffney Christopher,
Li Dongze,
Mao Jialin,
Nowels Molly,
Scherr Douglas S.,
Sedrakyan Art,
Hu Jim C.
Publication year - 2020
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.32821
Subject(s) - medicine , prostatectomy , prostate cancer , odds ratio , biopsy , concordance , radiology , magnetic resonance imaging , confidence interval , prostate biopsy , urology , watchful waiting , cancer
Background Adoption of prostate magnetic resonance imaging (MRI) before biopsy is based on evidence demonstrating superior detection of clinically significant prostate cancer on biopsy. Whether this is due to the detection of otherwise occult higher grade cancers or preferential sampling of higher grade areas within an otherwise low‐grade cancer is unknown. Methods To distinguish these two possibilities, this study examined the effect of prebiopsy MRI on the rate of pathologic upgrading and downgrading at prostatectomy in Surveillance, Epidemiology, and End Results–Medicare linked data from 2010 to 2015. Logistic regression was performed to assess the effect of MRI use on the Gleason grade change between biopsy and prostatectomy. Results Among biopsy‐naive men, those who underwent prebiopsy MRI had higher odds of downgrading at prostatectomy (odds ratio [OR], 1.32; 95% confidence interval [CI], 1.05‐1.66). In contrast, the odds of upgrading were significantly lower for men who underwent prebiopsy MRI (OR, 0.78; 95% CI, 0.61‐0.99). Limitations included a low overall rate of MRI‐utilization prior to biopsy and an inability to distinguish between template, software‐assisted and cognitive fusion biopsy. Conclusions Prebiopsy MRI is associated with both oversampling of higher grade areas, which results in downgrading at prostatectomy, and the detection of otherwise occult higher grade lesions, which results in less upgrading at prostatectomy.