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Correlations between imatinib plasma trough concentration and adverse reactions in Chinese patients with gastrointestinal stromal tumors
Author(s) -
Xia Yanzhe,
Chen Sile,
Luo Meijuan,
Wu Jingjing,
Cai Shirong,
He Yulong,
Chen Xiao,
Zhang Xinhua
Publication year - 2020
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.32751
Subject(s) - cmin , medicine , imatinib , gastroenterology , rash , adverse effect , gist , anemia , volume of distribution , nausea , cmax , pharmacokinetics , stromal cell , myeloid leukemia
Background Imatinib is the standard treatment for patients with gastrointestinal stromal tumors (GISTs), but there is significant variation in imatinib plasma trough concentrations (C min ) among patients. The imatinib C min distribution at different doses and the correlation of adverse reactions with C min in Chinese patients with GIST from a high‐volume center were evaluated. Methods From July 1, 2017 to December 31, 2018, patients who were receiving imatinib treatment for GIST were prospectively enrolled. Steady‐state blood samples were obtained from patients who had received same‐dose imatinib treatment for ≥1 month with good compliance. Adverse reactions were recorded during regular follow‐up, and blood samples were collected 24 ± 2 hours after dosing. Liquid chromatography‐tandem mass spectrometry was used to measure drug concentrations. Results In total, 307 patients who received 367 dose levels were investigated. The imatinib C min was 1315 ± 716 ng/mL, 2117 ± 597 ng/mL, and 3844 ± 987 ng/mL in patients who were receiving imatinib 400 mg, 600 mg, and 800 mg daily, respectively. The C min was significantly correlated with periorbital and limb edema ( P < .001), anemia ( P < .001), and rash ( P = .037). Nausea and vomiting, diarrhea, and conjunctival hemorrhage also were correlated, but not significantly. A much higher C min was observed with severe adverse reactions. There was no correlation between the imatinib C min and leukopenia, muscle cramps, or hepatobiliary dysfunction. Conclusions In Chinese patients with GIST, the imatinib C min was higher than that reported for Western populations, especially at higher doses. The C min was correlated with periorbital and limb edema, anemia, and rash, suggesting that monitoring the imatinib C min should be considered when patients develop severe adverse reactions caused by excessive imatinib plasma concentrations.