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Clinically ascertained health outcomes, quality of life, and social attainment among adult survivors of neuroblastoma: A report from the St. Jude Lifetime Cohort
Author(s) -
Wilson Carmen L.,
Brinkman Tara M.,
Cook Cathleen,
Huang Sujuan,
Hyun Geehong,
Green Daniel M.,
Furman Wayne L.,
Bhakta Nickhill,
Ehrhardt Matthew J.,
Krasin Matthew J.,
Robison Leslie L.,
Ness Kirsten K.,
Hudson Melissa M.
Publication year - 2020
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.32678
Subject(s) - medicine , quality of life (healthcare) , confidence interval , somatization , demography , cohort , common terminology criteria for adverse events , distress , anxiety , gerontology , pediatrics , adverse effect , psychiatry , clinical psychology , nursing , sociology
Background The objective of this study was to characterize chronic disease, health‐related quality of life (HRQOL), emotional distress, and social attainment among long‐term survivors of neuroblastoma. Methods Chronic health conditions among 136 ≥10‐year neuroblastoma survivors (median age, 31.9 years; range, 20.2‐54.6 years) and 272 community controls (median age, 34.7 years; range, 18.3‐59.6 years) were graded with a modified version of the Common Terminology Criteria for Adverse Events (version 4.03). HRQOL and emotional distress were assessed with the Medical Outcomes Study 36‐Item Short Form Health Survey and the Brief Symptom Inventory‐18. Log‐binomial regression and logistic regression were used to compare the prevalence of chronic conditions and the frequency of reduced HRQOL, distress, and social attainment between survivors and controls. The cumulative burden approach was used to estimate multimorbidity. Results By the age of 35 years, survivors had experienced, on average, 8.5 grade 1 to 5 conditions (95% confidence interval [CI], 7.6‐9.3), which was higher than the average for controls (3.3; 95% CI, 2.9‐3.7). Compared with controls, survivors had a higher prevalence of any pulmonary ( P = .003), auditory ( P < .001), gastrointestinal ( P < .001), neurological ( P = .003), or renal condition ( P < .001); were more likely to report poor physical HRQOL ( P = .01) and symptoms of anxiety ( P = .01) and somatization ( P = .01); and were less likely to live independently ( P = .01) or marry ( P = .01). In analyses limited to survivors, those with 1 or more grade 3 to 5 conditions were more likely to report reduced general health (odds ratio [OR], 6.6; 95% CI, 1.6‐26.9), greater bodily pain (OR, 4.2; 95% CI, 1.0‐17.0), and unemployment (OR, 3.2; 95% CI, 1.2‐8.5). Conclusions Because of the high burden of chronic diseases and the associations of these morbidities with reduced HRQOL and social attainment, screening and interventions that provide opportunities to optimize health are important among neuroblastoma survivors.