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Biomarkers in ovarian cancer: To be or not to be
Author(s) -
Arend Rebecca,
Martinez Alba,
Szul Tomasz,
Birrer Michael J.
Publication year - 2019
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.32595
Subject(s) - debulking , medicine , ovarian cancer , stage (stratigraphy) , epithelial ovarian cancer , cancer , oncology , medical physics , paleontology , biology
Biomarkers are becoming increasingly important in the treatment of epithelial ovarian cancer. Recent work from many laboratories has begun to provide clinically meaningful biomarkers. This review summarizes the state of the science regarding biomarkers for stratifying early‐stage patients into those who benefit from adjuvant treatment, primary debulking versus interval debulking, and specific targeted therapy. In addition, new molecular imaging technologies have been developed to allow the surgeon to resect subvisible tumor deposits. These efforts should increase clinical effectiveness while minimizing toxicities for patients.