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Two enemies, one fight: An update of oral cancer in patients with Fanconi anemia
Author(s) -
Amenábar José M.,
TorresPereira Cassius C.,
Tang Kai D.,
Punyadeera Chamindie
Publication year - 2019
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.32435
Subject(s) - medicine , fanconi anemia , bone marrow failure , cancer , population , head and neck cancer , anemia , leukemia , basal cell , cancer research , oncology , dna repair , gene , haematopoiesis , stem cell , genetics , biology , environmental health
Fanconi anemia (FA) is a rare inherited genetic condition that may lead to bone marrow failure, leukemia, and/or solid tumors. It is caused by the loss of function of at least 1 gene of the FA/BRCA pathway, which is necessary for DNA repair. Patients with FA have a 200‐fold to 1000‐fold risk of developing head and neck cancer, mainly oral squamous cell carcinoma (OSCC), and of doing so at a much younger age than individuals within the general population. Also, patients who have FA with OSCC have poor overall survival rates, reinforcing the necessity to detect OSCC early. The scope of the current review is to provide an update on OSCC in patients with FA.