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Multiple myeloma epidemiology and patient geographic distribution in Canada: A population study
Author(s) -
Tsang Matthew,
Le Michelle,
Ghazawi Feras M.,
Cyr Janelle,
Alakel Akram,
Rahme Elham,
Lagacé François,
Netchiporouk Elena,
Moreau Linda,
Zubarev Andrei,
Roshdy Osama,
Glassman Steven J.,
Sasseville Denis,
Popradi Gizelle,
Litvinov Ivan V.
Publication year - 2019
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.32128
Subject(s) - incidence (geometry) , demography , medicine , epidemiology , metropolitan area , population , distribution (mathematics) , latitude , cancer registry , geography , environmental health , pathology , mathematical analysis , physics , mathematics , geodesy , sociology , optics
Background Multiple myeloma (MM) is a malignancy of mature plasma cells. Environmental risk factors identified for this malignancy, among others, include farming and exposure to pesticides. Methods Using 3 independent population‐based databases (the Canadian Cancer Registry, le Registre Québécois du Cancer, and Canadian Vital Statistics), this study analyzed patients’ clinical characteristics and the incidence, mortality, and geographic distribution of MM cases in Canada during 1992‐2015. Results In total, ~32,065 patients were identified, and 53.7% were male. The mean age at the time of diagnosis was 70 ± 12.1 years. The average incidence rate in Canada was 54.29 cases per million individuals per year, and linear regression modeling showed a steady rise in the annual rate of 0.96 cases per million individuals per year. At the provincial level, Quebec and Ontario had significantly higher incidence rates than the rest of Canada. An analysis of individual municipalities and postal codes showed lower incidence rates in large metropolitan areas and in high‐latitude regions of the country, whereas high incidence rates were observed in smaller municipalities and rural areas. Land use analysis demonstrated increased density of crop farms and agricultural industries in high‐incidence areas. A comparison with the available data from 2011‐2015 showed several consistent trends at provincial, municipal, and regional levels. Conclusions These results provide a comprehensive analysis of the MM burden in Canada. Large metropolitan cities as well as high‐latitude regions were associated with lower MM incidence. Higher incidence rates were noted in smaller cities and rural areas and were associated with increased density of agricultural facilities.