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Entinostat finds a path: A new study elucidates effects of the histone deacetylase inhibitor on the immune system
Author(s) -
Surolia Ira,
Bates Susan E.
Publication year - 2018
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.31766
Subject(s) - histone deacetylase , histone deacetylase inhibitor , medicine , immune system , cancer research , histone , pharmacology , computational biology , bioinformatics , immunology , biology , genetics , gene
In this issue, Smith and colleagues demonstrate the antitumor effects of entinostat in an ovarian cancer model and reveal how the drug effects are mediated by the immune system. These studies finally have the potential to translate the unique activity of histone deacetylase inhibitors to solid tumors.