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To delay or not to delay, that is the question for patients with acute lymphoblastic leukemia who do not receive prophylactic cranial irradiation
Author(s) -
Pui ChingHon
Publication year - 2018
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.31756
Subject(s) - medicine , lumbar puncture , prophylactic cranial irradiation , lymphoblastic leukemia , central nervous system , leukemia , acute lymphocytic leukemia , clinical trial , oncology , pediatrics , surgery , cerebrospinal fluid , myocardial infarction , conventional pci
To determine the impact of delaying diagnostic lumbar puncture and initial intrathecal therapy on the treatment outcomes of children with newly diagnosed acute lymphoblastic leukemia treated without prophylactic cranial irradiation, Yeh and colleagues have updated their Taiwan Pediatric Oncology Group Acute Lymphoblastic Leukemia 2002 clinical trial. They have found that this treatment strategy reduces the rate of traumatic lumbar puncture with blasts to zero, and it tends to improve the outcomes of patients with a central nervous system 2 or 3 status according to the event‐free survival, the overall survival, and the cumulative risk of central nervous system relapse in comparison with historical controls.