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A phase 1, open‐label, dose escalation study of intravenous paricalcitol in combination with gemcitabine in patients with advanced malignancies
Author(s) -
Fountzilas Christos,
Javle Milind,
Tan Wei,
Ma Yingyu,
Fetterly Gerald,
Iyer Renuka,
Johnson Candace
Publication year - 2018
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.31676
Subject(s) - paricalcitol , medicine , gemcitabine , calcitriol , adverse effect , calcitriol receptor , pharmacology , pharmacokinetics , docetaxel , oncology , urology , chemotherapy , vitamin d and neurology , secondary hyperparathyroidism , parathyroid hormone , calcium
BACKGROUND Calcitriol, the active analogue of vitamin D, is antiproliferative and enhances the cytotoxicity of several anticancer agents, including gemcitabine. The vitamin D receptor (VDR) is expressed in the tumor stroma and treatment with VDR ligands results in stromal remodeling and increased intratumoral gemcitabine delivery. Furthermore, calcitriol can decrease the activity of the gemcitabine deactivating enzyme cytidine deaminase (CDD). Because hypercalcemia has been the most worrisome calcitriol‐related adverse event, the less hypercalcemic agent paricalcitol may be preferred for further investigation. METHODS The authors undertook a phase 1 study of gemcitabine in combination with escalating doses of paricalcitol administered weekly intravenously in patients with advanced cancers. A standard 3+3 dose escalation schema was used. Pharmacokinetic assessment of gemcitabine and its metabolite 2’,2’‐difluorodeoxyuridine (dFdU) was performed. Pharmacodynamic assessment of paricalcitol was performed by measurement of CDD activity in peripheral blood mononuclear cells. RESULTS A total of 44 patients were enrolled. Somnolence was the main dose‐limiting toxicity. The highest dose of paricalcitol administered was 10.5 µg/kg. Hypercalcemia was infrequent and mild in severity. Paricalcitol did not appear to affect the pharmacokinetics of gemcitabine and dFdU. Evaluation of CDD activity was available for 9 patients; no clear trend for CDD activity after treatment with paricalcitol was established. The overall response rate was 4%; the rate of disease control was 67% in patients who were pretreated with gemcitabine. Progression‐free and overall survival were 3.4 months and 6.5 months, respectively. CONCLUSIONS Paricalcitol can be administered safely in doses up to 7 µg/kg weekly with fixed dose rate gemcitabine without dose‐limiting hypercalcemia. To the best of the authors’ knowledge, the maximum tolerated dose has not been formally established to date. Preliminary clinical activity deserves further exploration.