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The tumor genome in human immunodeficiency virus–related head and neck cancer: Exploitable targets?
Author(s) -
Burtness Barbara
Publication year - 2018
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.31059
Subject(s) - apobec , head and neck cancer , genome , gene , virus , cancer , head and neck , virology , medicine , human immunodeficiency virus (hiv) , human genome , mutation , genetics , biology , surgery
In a small cohort of human immunodeficiency virus–related head and neck cancers, the majority are demonstrated to bear mutations in head and neck cancer–relevant genes, with some similarities to genomic profiles for human immunodeficiency virus–unrelated head and neck cancers. Although gene panels are not definitive for mutational signatures, the pattern of mutations is consistent with mutational signatures associated with the activity of the virally responsive APOBEC gene editing proteins. See also pages 84‐94.