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Early detection versus prevention in colorectal cancer screening: Methods estimates and public health implications
Author(s) -
Segnan Nereo,
Armaroli Paola
Publication year - 2017
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.31032
Subject(s) - medicine , colorectal cancer , adenomatous polyps , cancer prevention , public health , gynecology , oncology , intervention (counseling) , cancer , colonoscopy , pathology , nursing
The percentage of mortality reduction due to prevention via the removal of adenomatous polyps or to early detection using comparison of survivals in intervention and usual‐care groups is flawed by lead time. Herein, a simple alternative algorithm is used and approximately 79% of averted colorectal cancer deaths are found to be due to prevention in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Some implications for public health are discussed. See also pages 4815‐22.