Premium
Hodgkin lymphoma classification: Are we at a crossroads?
Author(s) -
Carbone Antonino,
Gloghini Annunziata
Publication year - 2017
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.30824
Subject(s) - germinal center , lymphoma , medicine , phenotype , follicular lymphoma , pathology , cd30 , hodgkin lymphoma , b cell , cancer research , gene , immunology , biology , genetics , antibody
On the basis of the putative origin from germinal center B cells, the gene expression profile, the expression of the B‐cell phenotype, and the propensity to progress toward large B‐cell lymphoma, nodular lymphocyte‐predominant Hodgkin lymphoma should be classified as a special type of B‐cell lymphoma with a follicular center cell origin. To guarantee the appropriate management of patients, information on the nodular growth patterns, the amount of (the number and the size) diffuse areas, and the tumor cell richness should be reported because of the clinical associations of these features.