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Decreased relapsed rate and treatment‐related mortality contribute to improved outcomes for pediatric acute myeloid leukemia in successive clinical trials
Author(s) -
Alexander Thomas B.,
Wang Lei,
Inaba Hiroto,
Triplett Brandon M.,
Pounds Stanley,
Ribeiro Raul C.,
Pui ChingHon,
Rubnitz Jeffrey E.
Publication year - 2017
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.30791
Subject(s) - medicine , cumulative incidence , myeloid leukemia , incidence (geometry) , hematopoietic stem cell transplantation , clinical trial , refractory (planetary science) , transplantation , randomized controlled trial , cancer , leukemia , disease , oncology , physics , astrobiology , optics
BACKGROUND Outcomes for children with acute myeloid leukemia (AML) have improved over the past 20 years even though the medications used for induction therapy have not changed. METHODS This study analyzed data from patients with AML who were enrolled in successive protocols (AML97 and AML02) to determine the contributors to the improved outcomes of the latter clinical trial. RESULTS There were significant improvements in 5‐year overall survival (48.9% vs 71.2%; P < .0001) and event‐free survival (43.5% vs 61.8%; P = .002) from AML97 to AML02. The 5‐year cumulative incidence of early death (ED)/treatment‐related mortality (TRM) was reduced for patients treated in AML02 (18.5% vs 7.9%; P = .007). Although the overall incidence of refractory disease (6.5% vs 5.6%; P = .736) and relapse (29.3% vs 21.0%; P = .12) did not differ between the 2 studies, patients with low‐risk AML who were treated in AML02 had a reduced incidence of relapse (27.3% vs 8.8%; P = .036). CONCLUSIONS The improved outcomes of the AML02 trial resulted from improved disease control for low‐risk patients and overall decreased ED/TRM. These results emphasize the importance of supportive‐care measures throughout chemotherapy courses and hematopoietic cell transplantation and the value of treatment intensity for patients with low‐risk AML while underscoring the need for novel therapy, rather than increased therapy intensity, for children with high‐risk AML. Cancer 2017;123:3791–3798. © 2017 American Cancer Society