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A comprehensive comparative analysis of treatment modalities for sinonasal malignancies
Author(s) -
Robin Tyler P.,
Jones Bernard L.,
Gordon Oren M.,
Phan Andy,
Abbott Diana,
McDermott Jessica D.,
Goddard Julie A.,
Raben David,
Lanning Ryan M.,
Karam Sana D.
Publication year - 2017
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.30686
Subject(s) - medicine , radiation therapy , chemoradiotherapy , propensity score matching , oncology , hazard ratio , multivariate analysis , lymph node , cancer , adjuvant therapy , stage (stratigraphy) , surgery , confidence interval , paleontology , biology
BACKGROUND Sinonasal malignancies are a rare and heterogeneous group of tumors for which there is a paucity of robust data with which to guide management decisions. The authors used the National Cancer Data Base to better understand the presenting characteristics of these tumors and to compare outcomes by treatment modality. METHODS The National Cancer Data Base was queried for sinonasal malignancies diagnosed between 2004 and 2012. Overall survival was assessed using multivariate analyses and propensity score matching. RESULTS A total of 11,160 patients were identified for the initial analysis. The majority were male, aged 40 to 69 years, with tumors of the nasal cavity or maxillary sinus. Squamous cell histology was most common. The majority of patients presented with advanced tumor stage but without locoregional lymph node or distant metastases. Treatment modalities were compared for squamous cell carcinomas. In multivariate analysis, compared with surgery alone, patients who received adjuvant radiotherapy (hazard ratio [HR], 0.658 [ P <.001]), adjuvant chemoradiotherapy (HR, 0.696 [ P = .002]), or neoadjuvant therapy (HR, 0.656 [ P = .007]) had improved overall survival. Patients who received radiotherapy alone (HR, 1.294 [ P = .001]) or chemotherapy alone (HR, 1.834 [ P <.001]) had worse outcomes. These findings were validated in propensity score matching. It is important to note that neoadjuvant chemoradiotherapy was associated with achieving a negative surgical margin (odds ratio, 2.641 [ P = .045]). CONCLUSIONS Surgery is the mainstay of therapy for patients with sinonasal malignancies, but multimodality therapy is associated with improved overall survival. Cancer 2017;123:3040–49. © 2017 American Cancer Society .