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Genetically engineered mouse models of melanoma
Author(s) -
PérezGuijarro Eva,
Day ChiPing,
Merlino Glenn,
Zaidi M. Raza
Publication year - 2017
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.30684
Subject(s) - genetically engineered , melanoma , medicine , computational biology , disease , cancer , genetic model , cancer research , biology , gene , genetics , pathology
Melanoma is a complex disease that exhibits highly heterogeneous etiological, histopathological, and genetic features, as well as therapeutic responses. Genetically engineered mouse (GEM) models provide powerful tools to unravel the molecular mechanisms critical for melanoma development and drug resistance. Here, we expound briefly the basis of the mouse modeling design, the available technology for genetic engineering, and the aspects influencing the use of GEMs to model melanoma. Furthermore, we describe in detail the currently available GEM models of melanoma. Cancer 2017;123:2089‐103 . © 2017 American Cancer Society .