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The utility of abbreviated patient‐reported outcomes for predicting survival in early stage colorectal cancer
Author(s) -
Hsu Tina,
Speers Caroline H.,
Kennecke Hagen F.,
Cheung Winson Y.
Publication year - 2017
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.30511
Subject(s) - medicine , colorectal cancer , psychosocial , hazard ratio , quality of life (healthcare) , cancer , proportional hazards model , stage (stratigraphy) , anxiety , disease , oncology , lung cancer , breast cancer , confidence interval , psychiatry , biology , paleontology , nursing
BACKGROUND Patient‐reported outcomes (PROs) are increasingly used in clinical settings. Prior research suggests that PROs collected at baseline may be associated with cancer survival, but most of those studies were conducted in patients with breast or lung cancer. The objective of this study was to determine the correlation between prospectively collected PROs and cancer‐specific outcomes in patients with early stage colorectal cancer. METHODS Patients who had newly diagnosed stage II or III colorectal cancer from 2009 to 2010 and had a consultation at the British Columbia Cancer Agency completed the brief Psychosocial Screen for Cancer (PSSCAN) questionnaire, which collects data on patients' perceived social supports, quality of life (QOL), anxiety and depression, and general health. PROs from the PSSCAN were linked with the Gastrointestinal Cancers Outcomes Database, which contains information on patient and tumor characteristics, treatment details, and cancer outcomes. Cox regression models were constructed for overall survival (OS), and Fine and Gray regression models were developed for disease‐specific survival (DSS). RESULTS In total, 692 patients were included. The median patient age was 67 years (range, 26‐95 years), and the majority had colon cancer (61%), were diagnosed with stage III disease (54%), and received chemotherapy (58%). In general, patients felt well supported and reported good overall health and QOL. On multivariate analysis, increased fatigue was associated with worse OS (hazard ratio [HR], 1.99; P = .00007) and DSS (HR, 1.63; P = .03), as was lack of emotional support (OS: HR, 4.36; P = .0003; DSS: HR, 1.92; P = .02). CONCLUSIONS Although most patients described good overall health and QOL and indicated that they were generally well supported, patients who experienced more pronounced fatigue or lacked emotional support had a higher likelihood of worse OS and DSS. These findings suggest that abbreviated PROs can inform and assist clinicians to identify patients who have a worse prognosis and may need more vigilant follow‐up. Cancer 2017;123:1839–1847 . © 2017 American Cancer Society .