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The population impact of human papillomavirus/cytology cervical cotesting at 3‐year intervals: Reduced cervical cancer risk and decreased yield of precancer per screen
Author(s) -
Silver Michelle I.,
Schiffman Mark,
Fetterman Barbara,
Poitras Nancy E.,
Gage Julia C.,
Wentzensen Nicolas,
Lorey Thomas,
Kinney Walter K.,
Castle Philip E.
Publication year - 2016
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.30277
Subject(s) - medicine , cohort , colposcopy , cervical intraepithelial neoplasia , cervical screening , cervical cancer , gynecology , population , cancer , obstetrics , cohort study , human papillomavirus , environmental health
BACKGROUND The objective of cervical screening is to detect and treat precancer to prevent cervical cancer mortality and morbidity while minimizing overtreatment of benign human papillomavirus (HPV) infections and related minor abnormalities. HPV/cytology cotesting at extended 5‐year intervals currently is a recommended screening strategy in the United States, but the interval extension is controversial. In the current study, the authors examined the impact of a decade of an alternative, 3‐year cotesting, on rates of precancer and cancer at Kaiser Permanente Northern California. The effect on screening efficiency, defined as numbers of cotests/colposcopy visits needed to detect a precancer, also was considered. METHODS Two cohorts were defined. The “open cohort” included all women screened at least once during the study period; > 1 million cotests were performed. In a fixed “long‐term screening cohort,” the authors considered the cumulative impact of repeated screening at 3‐year intervals by restricting the cohort to women first cotested in 2003 through 2004 (ie, no women entering screening later were added to this group). RESULTS Detection of cervical intraepithelial neoplasia 3/adenocarcinoma in situ (CIN3/AIS) increased in the open cohort (2004‐2006: 82.0/100,000 women screened; 2007‐2009: 140.6/100,000 women screened; and 2010‐2012: 126.0/100,000 women screened); cancer diagnoses were unchanged. In the long‐term screening cohort, the detection of CIN3/AIS increased and then decreased to the original level (2004‐2006: 80.5/100,000 women screened; 2007‐2009: 118.6/100,000 women screened; and 2010‐2012: 84.9./100,000 women screened). The number of cancer diagnoses was found to decrease. When viewed in terms of screening efficiency, the number of colposcopies performed to detect a single case of CIN3/AIS increased in the cohort with repeat screening. CONCLUSIONS Repeated cotesting at a 3‐year interval eventually lowers population rates of precancer and cancer. However, a greater number of colposcopies are required to detect a single precancer. Cancer 2016;122:3682‐6. © 2016 American Cancer Society .