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Clinical outcomes in metastatic uveal melanoma treated with PD‐1 and PD‐L1 antibodies
Author(s) -
Algazi Alain P.,
Tsai Katy K.,
Shoushtari Alexander N.,
Munhoz Rodrigo R.,
Eroglu Zeynep,
Piulats Josep M.,
Ott Patrick A.,
Johnson Douglas B.,
Hwang Jimmy,
Daud Adil I.,
Sosman Jeffrey A.,
Carvajal Richard D.,
Chmielowski Bartosz,
Postow Michael A.,
Weber Jeffrey S.,
Sullivan Ryan J.
Publication year - 2016
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.30258
Subject(s) - medicine , ipilimumab , pembrolizumab , nivolumab , melanoma , atezolizumab , oncology , surgery , gastroenterology , cancer , immunotherapy , cancer research
BACKGROUND Antibodies inhibiting the programmed death receptor 1 (PD‐1) have demonstrated significant activity in the treatment of advanced cutaneous melanoma. The efficacy and safety of PD‐1 blockade in patients with uveal melanoma has not been well characterized. METHODS Fifty‐eight patients with stage IV uveal melanoma received PD‐1 or PD‐1 ligand (PD‐L1) antibodies between 2009 and 2015 at 9 academic centers. Patients who were evaluable for response were eligible for the analysis. Imaging was performed every 12 weeks and at the investigators' discretion. Safety and clinical efficacy outcomes, including the best overall response, progression‐free survival (PFS), and overall survival (OS), were retrospectively determined. RESULTS Of 56 eligible patients, 48 (86%) had received prior therapy, and 35 (63%) had received treatment with ipilimumab. Three patients had an objective response to ipilimumab, and 8 had stable disease as their best response. Thirty‐eight patients (68%) received pembrolizumab, 16 (29%) received nivolumab, and 2 (4%) received atezolizumab. Objective tumor responses were observed in 2 patients for an overall response rate of 3.6% (95% confidence interval [CI], 1.8%‐22.5%). Stable disease (≥6 months) was observed in 5 patients (9%). The median PFS was 2.6 months (95% CI, 2.4‐2.8 months), and the median OS was 7.6 months (95% CI, 0.7‐14.6 months). There was no association between prior treatment with ipilimumab or liver‐directed therapy and PFS or OS. Treatment was well tolerated, and only 1 patient discontinued treatment because of toxicity. CONCLUSIONS PD‐1 and PD‐L1 antibodies rarely confer durable remissions in patients with metastatic uveal melanoma. Clinical trial enrollment should be prioritized in this population. Cancer 2016;122:3344–3353 . © 2016 American Cancer Society .