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Racial disparities in the survival of American children, adolescents, and young adults with acute lymphoblastic leukemia, acute myelogenous leukemia, and Hodgkin lymphoma
Author(s) -
Kahn Justine M.,
Keegan Theresa H.M.,
Tao Li,
Abrahão Renata,
Bleyer Archie,
Viny Aaron D.
Publication year - 2016
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.30089
Subject(s) - medicine , young adult , leukemia , pediatrics , survival analysis , lymphoma , oncology
BACKGROUND Race‐based survival in children and adolescents with hematologic malignancies has been a national challenge for decades. Large‐scale investigations of age‐ and race‐based survival trends over time in these patients have not previously been reported. The objective of this study was to investigate whether race‐ and age‐related differences in pediatric and adolescent and young adult (AYA) leukemia and lymphoma survival persist and to what extent these differences have changed over time. METHODS Using the Surveillance, Epidemiology, and End Results program, this study investigated the outcomes of black and white (1975‐2012; n = 27,369) and white and Hispanic (1992‐2012; n = 20,574) children (0‐14 years old) and AYAs (15‐39 years old) with acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), and Hodgkin lymphoma (HL). Estimates of 5‐ and 10‐year relative survival were compared over time. RESULTS Trends showed a convergence of survival for white and black children with ALL but a divergence in survival for AYA patients. Hispanic children and AYAs both suffered inferior outcomes. Trends for AML revealed persistent survival differences between black and white children and suggested worsening disparities for AYAs. Survival trends in HL revealed sustained survival differences between black and white AYA patients, whereas no differences were found in Hispanic and white patient outcomes for AML or HL. CONCLUSIONS Although survival for children and AYAs with ALL, AML, and HL has improved over the past 4 decades, differences persist between black, white, and Hispanic children and AYAs; survival disparities between black and white children with ALL have been nearly eliminated. Strategies aimed at identifying causality and reducing disparities are warranted. Cancer 2016 . © 2016 American Cancer Society . Cancer 2016;122:2723–2730. © 2016 American Cancer Society.