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Childhood acute lymphoblastic leukemia: Integrating genomics into therapy
Author(s) -
Tasian Sarah K.,
Loh Mig L.,
Hunger Stephen P.
Publication year - 2015
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.29573
Subject(s) - medicine , malignancy , lymphoblastic leukemia , epigenomics , childhood cancer , risk stratification , genomics , cancer , precision medicine , leukemia , oncology , intensive care medicine , immunology , genome , dna methylation , genetics , pathology , biology , gene , gene expression
Acute lymphoblastic leukemia (ALL), the most common malignancy of childhood, is a genetically complex entity that remains a major cause of childhood cancer‐related mortality. Major advances in genomic and epigenomic profiling during the past decade have appreciably enhanced knowledge of the biology of de novo and relapsed ALL and have facilitated more precise risk stratification of patients. These achievements have also provided critical insights regarding potentially targetable lesions for the development of new therapeutic approaches in the era of precision medicine. In this review, the authors delineate the current genetic landscape of childhood ALL, emphasizing patient outcomes with contemporary treatment regimens as well as therapeutic implications of newly identified genomic alterations in specific subsets of ALL. Cancer 2015;121:3577–3590 . © 2015 American Cancer Society .