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Histone deacetylase inhibitors in cancer: What have we learned?
Author(s) -
Whittle James R.,
Desai Jayesh
Publication year - 2015
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.29177
Subject(s) - histone deacetylase , medicine , histone deacetylase inhibitor , histone , cancer , cancer research , oncology , biology , genetics , gene
The authors outline the current stage in the development of histone deacetylase inhibitors in solid tumors. Despite single‐agent benefit in a small number of hematologic malignancies, evidence in solid organ cancers suggests that outcomes will be more promising with combination therapy and should be the focus of future studies.