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Oncolytic polio virotherapy of cancer
Author(s) -
Brown Michael C.,
Dobrikova Elena Y.,
Dobrikov Mikhail I.,
Walton Ross W.,
Gemberling Sarah L.,
Nair Smita K.,
Desjardins Annick,
Sampson John H.,
Friedman Henry S.,
Friedman Allan H.,
Tyler Douglas S.,
Bigner Darell D.,
Gromeier Matthias
Publication year - 2014
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.28862
Subject(s) - oncolytic virus , virotherapy , medicine , immunotherapy , cancer immunotherapy , cancer , immunology , virology , cancer research , immune system
Recently, the century‐old idea of targeting cancer with viruses ( oncolytic viruses ) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity ( oncolytic virotherapy ), recently, the proinflammatory and immunogenic effects of viral tumor infection ( oncolytic immunotherapy ) have come into focus. Indeed, a capacity for eliciting broad, sustained antineoplastic effects stemming from combined direct viral cytotoxicity, innate antiviral activation, stromal proinflammatory stimulation, and recruitment of adaptive immune effector responses is the greatest asset of oncolytic viruses. However, it also is the source for enormous mechanistic complexity that must be considered for successful clinical translation. Because of fundamentally different relationships with their hosts (malignant or not), diverse replication strategies, and distinct modes of tumor cytotoxicity/killing, oncolytic viruses should not be referred to collectively. These agents must be evaluated based on their individual merits. In this review, the authors highlight key mechanistic principles of cancer treatment with the polio:rhinovirus chimera PVSRIPO and their implications for oncolytic immunotherapy in the clinic. Cancer 2014;120:3277–3286. © 2014 American Cancer Society .